Ionizing radiation breast cancer

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Radiation therapy is a treatment for cancer and, less commonly, thyroid disease, blood disorders, and noncancerous growths. A doctor may recommend radiation for cancer at different stages. In the early stages, radiation therapy can help reduce the size of a tumor before surgery or kill remaining cancer cells afterward.

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Radiation occurs naturally all around us from sources such as the sun, rocks, soil, buildings, air, food and drink. The scientific unit of measurement for radiation dose is millisieverts mSv. In Australia the average background radiation dose is about 2.

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Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer. Breast cancer is the most common malignancy in women. Radiotherapy is frequently used in patients with breast cancer, but some patients may be more susceptible to ionizing radiation, and increased exposure to radiation sources may be associated to radiation adverse events.

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All human beings are exposed to the influence of ionizing radiation from natural, medical and other artificial sources. Therefore, the influence of radiation as a risk factor for cancer development has been among the most studied external factors over the last 6 decades, particularly with respect to radiosensitive tissues and organs. It has been known that female breast tissue is highly sensitive to the carcinogenic effects of radiation, particularly when exposure takes place at younger age.

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The purposes of this study were to determine whether exposure of the vestigial male breast to ionizing radiation is associated with an increase in risk of breast cancer and, if so, to determine whether the apparent effects on risk in men are similar to those reported for women. A population-based case-control study of breast cancer in men was conducted in 10 geographic areas of the United States. Information on possible prior exposure to ionizing radiation, and on other potential risk factors for breast cancer, was obtained from personal interviews of cases and controls who were recruited from October to September

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Disclosure: Philippe F. Simard: None; Rachel M. Bolton: None; Nancy J.

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This paper summarizes current knowledge on ionizing radiation-associated breast cancer in the context of established breast cancer risk factors, the radiation dose—response relationship, and modifiers of dose response, taking into account epidemiological studies and animal experiments. Available epidemiological data support a linear dose—response relationship down to doses as low as about mSv. However, the magnitude of risk per unit dose depends strongly on when radiation exposure occurs: exposure before the age of 20 years carries the greatest risk.

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Radiation of certain wavelengths, called ionizing radiationhas enough energy to damage DNA and cause cancer. Ionizing radiation includes radon, x-rays, gamma rays, and other forms of high-energy radiation. Lower-energy, non-ionizing forms of radiation, such as visible light and the energy from cell phoneshave not been found to cause cancer in people.

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Radiation therapy or radiotherapyoften abbreviated RTRTxor XRTis therapy using ionizing radiationgenerally as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator. Radiation therapy may be curative in a number of types of cancer if they are localized to one area of the body. It may also be used as part of adjuvant therapyto prevent tumor recurrence after surgery to remove a primary malignant tumor for example, early stages of breast cancer.

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Background: Intraoperative electron radiation therapy IOERT is a therapeutic technique which administers a single high dose of ionizing radiation immediately after surgical tumor removal. IOERT induces a strong stress response: both tumor and normal cells activating pro- and antiproliferative cell signaling pathways. Following treatment, several genes and factors are differently modulated, producing an imbalance in cell fate decision. However, the contribution of these genes and pathways in conferring different cell radiosensitivity and radioresistance needs to be further investigated, in particular after high-dose treatments.

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